pubmed: Cytochrome P450 Huma… pubmed: Pharmacogenetics Hum… pubmed: Drug Interactions Hu…The FDA announced yesterday that the Carbamazepine drug label will now recommend HLA-B* 1502 genetic testing of patients with Asian ancestry prior to initiation of therapy. About 6 in 1000 Asian patients have a variation of this immune system gene that increases the risk for developing Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug [...]
Filed under: Personalized Medicine, Recommended Links | Leave a Comment »
A case and comment are reported in Currents in Affective Medicine Nov 2007 which reflect an interesting drug-drug interaction. A child with OCD was well treated with clomipramine 150mg/day. A diagnosis of bipolar disorder while he was in the hospital was treated with oxcarbazepine 600mg bid. The treater states that the child’s sleep improved as [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine | Tagged: drugs, interactions, medications, Personalized Medicine | Leave a Comment »
AHRQ’s Evidence Report on Depression, CYP450 Testing for Adults Treated with SSRIs concluded “There is a paucity of good-quality data addressing the questions of whether testing for CYP450 polymorphisms in adults entering SSRI treatment for non-psychotic depression leads to improvement in outcomes, or whether testing results are useful in medical, personal, or public health decisionmaking.” [...]
Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: DNA, Personalized Medicine, Pharmacogenetics | 1 Comment »
J Psychosoc Nurs Ment Health Serv. 2007 Oct;45(10):15-8. Link: Cytochrome P450 testing for better psychiatric care. Pestka EL, Hale AM, Johnson BL, Lee JL, Poppe KA. Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. pestka.elizabeth@mayo.edu Genotyping for CYP2D6 and CYP2C19 variations is emerging as a potentially useful clinical tool to help mental [...]
Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: Cytochrome, DNA, Pharmacogenetic, psychiatry | 1 Comment »
