Effect of Terbinafine and Voriconazole on the Pharmacokinetics of the Antidepressant Venlafaxine

Posted on February 7, 2008 by DNADiva

Comment from Jessica Oesterheld, M.D.:  Although not reported before based on a clinical study, this significant drug interaction is entirely predictable since it is known that terbinafine is a potent inhibitor of CYP2D6 and venlafaxine’s major metabolic pathway is CYP2D6. Venlafaxine’s adverse effects are known to include increased blood pressure at higher doses as well [...]

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Heath Ledger’s Accidental Overdose

Posted on February 7, 2008 by DNADiva

Considering that adverse drug reactions are the fourth leading cause of death- responsible for taking over 100,000 U.S. lives per year; you’d think the problem would get more attention. With the recent scare with Dennis Quaid’s children’s accidental heperin overdose and now Heath Ledger’s accidental overdose, maybe this serious public health problem will begin [...]

Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine, Pharmacogenetics | Leave a Comment »