Drug-drug interactions in a geriatric outpatient cohort

COMMENT: This article speaks to the clinical significance of drug interactions in a particularly susceptible population, the elderly. ABSTRACT: Drugs Aging. 2008;25(4):343-55. Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance. Tulner LR, Frankfort SV, Gijsen GJ, van Campen JP, Koks CH, Beijnen JH. Department of Geriatric Medicine, Slotervaart Hospital, Amsterdam, the Netherlands. BACKGROUND: [...]

Comparison of two immortalized human cell lines to study nuclear receptor mediated CYP3A4 induction

Harmsen S, Koster A, Beijnen JH, Schellens JH, Meijerman I.Utrecht University. Since cytochrome P450 3A4 (CYP3A4) is responsible for the biotransformation of over 50% of all clinically used drugs, induction results in an increased clearance of many concomitantly administered drugs, thereby decreasing treatment efficacy or, in the case of pro-drugs, lead to severe intoxications. CYP3A4 [...]

Pharmacokinetic interactions between contraceptives and antiepileptic drugs

COMMENT: This is a short review of an important subject especially for psychiatrists and neurologists. Apart from the usual warnings about inactivating the effects of oral contraceptives (OCs) by the antiepileptic potent CYP3A4 inducers (e.g., phenobarbital, phenytoin, etc), there is also a warning about the induction BY oral contraceptives of the UGTs responsible for lamotrigine [...]

CYP2C19*17

COMMENT: Only in the last year has a new allele of CYP2C19 been recognized. CYP2C19*17 is associated with ultrarapid metabolizer status. Omeprazole is not only a probe drug for this CYP, but it is a widely used PPI throughout the world. The fact that individual who are homozygotic for this allele will have 2.1-fold lower [...]

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions

COMMENT: Research about the ABC transporters has been skyrocketing in the last 3 years. These transporters also are involved in drug transport in many organs of the body including both reabsorption and tubular secretion in the kidney. Best known of this group, ABCB1 or also known as p-glycoprotein has occupied the forefront of research. Like [...]

Effect of multiple doses of montelukast on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans

COMMENT: At first, montelukast was believed to be an inhibitor of multiple CYPs because of invitro evidence. In 2005, had it been shown that it was a selective invitro CYP2C8 inhibitor (PMID 15608135). However, the study below shows unequivocally that it is not a CYP2C8 inhibitor in vivo. ABSTRACT: Br J Clin Pharmacol. 2007 Mar;63(3):339-45. [...]

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