pubmed: Cytochrome P450 Huma… pubmed: Pharmacogenetics Hum… pubmed: Drug Interactions Hu…“The thing that hit me in the face, was that virtually all the events were in those homozygotes” - Dr. C. Michael Gibson, Duke University Dr. Gibson and Dr. Kirtane from Duke University reconsider genetic testing for CYP2C19 based on the GIFT sub-study of GRAVITAS presented last week at ACC. The study clearly showed that [...]
Filed under: Personalized Medicine | Tagged: CYP, CYP219, Cytochrome, Personalized Medicine, Pharmacogenetics, plavix | Leave a Comment »
JAMA released more research today that further confirms the importance of CYP2D6 testing to determine tamoxifen efficacy. Full details at http://jama.ama-assn.org/cgi/content/short/302/13/1429. The conclusion: Recurrence Rates: 14.9% for extensive metabolizers 20.9% for intermediate metabolizers 29.0% for poor metabolizers This means that Extensive Metabolizers will get the same preventative outcome from tamoxifen as much more expensive aromatase [...]
Filed under: Personalized Medicine | Tagged: breast cancer, CYP, CYP2D6, Cytochrome, JAMA, Personalized Medicine, Pharmacogenetics, tamoxifen | Leave a Comment »
Pharmacogenomics J. 2009 May 19. Intermediate metabolizer: increased side effects in psychoactive drug therapy. The key to cost-effectiveness of pretreatment CYP2D6 screening? Laika B, Leucht S, Heres S, Steimer W. Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, München, Germany. The cytochrome P450 2D6 (CYP2D6) isoenzyme metabolizes about 25% of [...]
Filed under: Personalized Medicine | Tagged: 2Dy, CYP2D6, Cytochrome, Personalized Medicine, Pharmacogenetics | Leave a Comment »
Drug Metab Dispos. 2008 Dec 12 Talakad JC, Kumar S, Halpert JR. University of California San Diego. Cytochrome P450 (CYP) 2B6 metabolizes a number of clinically relevant drugs and is one of the most highly polymorphic human P450 enzymes, with the Lys(262)–>Arg substitution being especially common in several genetic variants. Therefore, K262R (2B6*4) was created [...]
Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: Cytochrome, Cytochrome P450, cytochromes, Personalized Medicine, Pharmacogenetics | 1 Comment »
Mayo gave a presentation yesterday at the 31st annual San Antonio Breast Cancer Symposium that further confirms the importance of the liver enzyme CYP2D6 in tamoxifen effectiveness. Tamoxifen is often prescribed to block the effects of estrogen in breast tissue to prevent breast cancer recurrence in ER+ (estrogen receptor positive) cancers which require estrogen to [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine, Pharmacogenetics | Tagged: breast cancer, CYP2D6, Cytochrome, genotyping, persoanlized medicine, tamoxifen | 1 Comment »
Harmsen S, Koster A, Beijnen JH, Schellens JH, Meijerman I.Utrecht University. Since cytochrome P450 3A4 (CYP3A4) is responsible for the biotransformation of over 50% of all clinically used drugs, induction results in an increased clearance of many concomitantly administered drugs, thereby decreasing treatment efficacy or, in the case of pro-drugs, lead to severe intoxications. CYP3A4 [...]
Filed under: Cytochrome P450, Personalized Medicine | Tagged: CYP3A, Cytochrome, INDUCTION | Leave a Comment »
Dr Oesterheld’s Comment: Silymarin (aka silibinin, silybin) is an extract of milk thistle, an antioxidant herbal that is being tested in a variety of conditions, diabetes, cancer and liver injury and others was originally shown to have in vitro inhibiton against CYP3A4. Two studies, one vitro and one in vivo studies have shown that its [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine, Pharmacogenetics | Tagged: 3A4, CYP, Cytochrome, Drug Interactions, interactions, pharamcogenetics. cytochrome p450, silymarin | Leave a Comment »
Dr. Oesterheld’s Comment: Although clinicians may be well aware of the potential of grapefruit juice to be an inhibitor of CYP3A4, only a few may be aware of the possibility of other CYP-based food- drug interactions.In this study, fennel, an herb and alternate drug is shown to be a modest CYP3A4 inhibitor. Since its inhibition [...]
Filed under: Cytochrome P450, Drug Interactions, Personalized Medicine | Tagged: 3A4, Cytochrome, Drug Interactions, fennel, P450, Personalized Medicine | Leave a Comment »
J Psychosoc Nurs Ment Health Serv. 2007 Oct;45(10):15-8. Link: Cytochrome P450 testing for better psychiatric care. Pestka EL, Hale AM, Johnson BL, Lee JL, Poppe KA. Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. pestka.elizabeth@mayo.edu Genotyping for CYP2D6 and CYP2C19 variations is emerging as a potentially useful clinical tool to help mental [...]
Filed under: Cytochrome P450, Personalized Medicine, Pharmacogenetics | Tagged: Cytochrome, DNA, Pharmacogenetic, psychiatry | 1 Comment »
| S | M | T | W | T | F | S |
|---|---|---|---|---|---|---|
| « Apr | ||||||
| 1 | 2 | 3 | ||||
| 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 |
| 25 | 26 | 27 | 28 | 29 | 30 | 31 |
